GHRP-2 vs MK-677: side-by-side comparison
Pralmorelin · Growth Hormone Releasing Peptide 2 · KP-102
A synthetic hexapeptide ghrelin mimetic that stimulates growth hormone release by binding to the growth hormone secretagogue receptor (GHS-R1a). More potent than GHRP-6 with fewer side effects, particularly less appetite stimulation. Often combined with GHRH peptides (Mod GRF/CJC-1295) for synergistic GH release.
Ibutamoren · MK677 · Nutrobal
An oral ghrelin mimetic that stimulates GH pulses. Technically not a peptide but a non-peptide agonist of the ghrelin receptor that increases growth hormone and IGF-1 levels.
4 / 10 natty scale / 4
Same lane
Both sit in the same class and are run for recovery. This is a like-for-like comparison: read the gaps as real trade-offs.
The tape
Core ratings
The same three rulers every entry on the site is scored with, read head to head.
Natty scale
1 natural · 10 heavy
Effectiveness
Documented effect · of 5Δ0.5
Side-effect severity
Documented burden · of 5Δ1
Cost side
Body-load fingerprint
Where each one actually lands its strain, on the calculator's thirteen channels. Tap a row for what it means and which labs track it.
Cardiometabolic
Organ strain
Hormonal
Systemic
Injection & site care
Bars show strain at each one's typical protocol, not your dose. ≈ marks values inferred from side-effect data or category rather than hand-graded. For your numbers, run the calculator.
Logistics
The vitals
Benefit side
What each is for
Shared goals carry both dots; a goal with one dot belongs to that side alone.
Run for
Documented upside
- More potent GH release than GHRP-6 (lower ED50)
- Minimal appetite stimulation compared to GHRP-6
- Lower cortisol and prolactin elevation than GHRP-6
- Signals via the GHS-R1a / PLC-PKC pathway, complementary and synergistic with GHRH analogs
- Low desensitization risk at standard doses
Run for
Documented upside
- Oral administration (no injections)
- Improved sleep quality
- Increased appetite
- Elevated IGF-1 levels
- Enhanced recovery
The downsides
Side effects, aligned
Each entry's documented side effects, sorted onto the same body systems so the gaps and the overlaps are visible. Tap any effect for the detail.
None documented
None documented
None documented
None documented
The exit
Hormonal fallout & recovery
What each does to your own hormone axis while on, and what leaving it costs.
GHRP-2
Does not affect HPT axis. No PCT required.
MK-677
Does not suppress testosterone. No PCT required.
Read-out
How they separate
- 01
Enhancement
They land at almost the same point on the natty scale (4/10 vs 4/10): a similar distance beyond natural.
- 02
Side-effect bill
MK-677's documented side-effect severity is heavier (3/5 vs 2/5). The body-load fingerprint above shows where that weight actually lands.
- 03
Body load
The widest gap at typical protocols is prolactin (GHRP-2 3.2/10 vs 0/10), then kidney load (MK-677 2.8/10 vs 0/10).
- 04
Coming off
Neither requires PCT: both leave the natural testosterone axis running.
- 05
Logistics
GHRP-2 runs as subcutaneous, MK-677 as oral; typical runs are 4-12 weeks vs 8-12 weeks.
- 06
Tested athletes
Both are WADA-prohibited: neither belongs anywhere near tested competition.
Generated from each entry's data file. Descriptive, not a recommendation; nothing here is medical advice.