GHRP-2 vs GHRP-6: side-by-side comparison
Pralmorelin · Growth Hormone Releasing Peptide 2 · KP-102
A synthetic hexapeptide ghrelin mimetic that stimulates growth hormone release by binding to the growth hormone secretagogue receptor (GHS-R1a). More potent than GHRP-6 with fewer side effects, particularly less appetite stimulation. Often combined with GHRH peptides (Mod GRF/CJC-1295) for synergistic GH release.
Growth Hormone Releasing Peptide 6 · Growth Hormone Releasing Hexapeptide · SK&F 110679
A synthetic hexapeptide ghrelin mimetic that was one of the first GH secretagogues developed. Stimulates growth hormone release through the GHS-R1a receptor. Known for causing intense appetite stimulation (the "hunger peptide"), which can be beneficial for bulking but problematic for cutting. Less selective than GHRP-2 with higher cortisol and prolactin elevation.
4 / 10 natty scale / 4
Same lane
Both sit in the same class and are run for recovery, performance. This is a like-for-like comparison: read the gaps as real trade-offs.
The tape
Core ratings
The same three rulers every entry on the site is scored with, read head to head.
Natty scale
1 natural · 10 heavy
Effectiveness
Documented effect · of 5
Side-effect severity
Documented burden · of 5Δ0.5
Cost side
Body-load fingerprint
Where each one actually lands its strain, on the calculator's thirteen channels. Tap a row for what it means and which labs track it.
Cardiometabolic
Hormonal
Injection & site care
Bars show strain at each one's typical protocol, not your dose. ≈ marks values inferred from side-effect data or category rather than hand-graded. For your numbers, run the calculator.
Logistics
The vitals
Benefit side
What each is for
Shared goals carry both dots; a goal with one dot belongs to that side alone.
Run for
Documented upside
- More potent GH release than GHRP-6 (lower ED50)
- Minimal appetite stimulation compared to GHRP-6
- Lower cortisol and prolactin elevation than GHRP-6
- Signals via the GHS-R1a / PLC-PKC pathway, complementary and synergistic with GHRH analogs
- Low desensitization risk at standard doses
Run for
Documented upside
- Slightly higher peak GH levels than GHRP-2
- Powerful appetite stimulation for bulking/hard gainers
- Lower receptor affinity than hexarelin means slower/milder desensitization at standard saturation doses
- Synergistic when combined with GHRH peptides
- Well-studied with extensive research data
The downsides
Side effects, aligned
Each entry's documented side effects, sorted onto the same body systems so the gaps and the overlaps are visible. Tap any effect for the detail.
The exit
Hormonal fallout & recovery
What each does to your own hormone axis while on, and what leaving it costs.
GHRP-2
Does not affect HPT axis. No PCT required.
GHRP-6
Does not affect HPT axis. No PCT required.
Read-out
How they separate
- 01
Enhancement
They land at almost the same point on the natty scale (4/10 vs 4/10): a similar distance beyond natural.
- 02
Side-effect bill
GHRP-6's documented side-effect severity is heavier (2.5/5 vs 2/5). The body-load fingerprint above shows where that weight actually lands.
- 03
Body load
The widest gap at typical protocols is estrogen load (GHRP-6 4/10 vs 1.7/10), then blood pressure (GHRP-6 3.2/10 vs 1.7/10).
- 04
Coming off
Neither requires PCT: both leave the natural testosterone axis running.
- 05
Tested athletes
Both are WADA-prohibited: neither belongs anywhere near tested competition.
Generated from each entry's data file. Descriptive, not a recommendation; nothing here is medical advice.