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GHRP-2 vs Tesamorelin: side-by-side comparison

GH Secretagogue

Pralmorelin · Growth Hormone Releasing Peptide 2 · KP-102

A synthetic hexapeptide ghrelin mimetic that stimulates growth hormone release by binding to the growth hormone secretagogue receptor (GHS-R1a). More potent than GHRP-6 with fewer side effects, particularly less appetite stimulation. Often combined with GHRH peptides (Mod GRF/CJC-1295) for synergistic GH release.

4.0/10 natty
Full breakdown →
VS
GH Secretagogue

Egrifta

A GHRH analog FDA-approved for reducing visceral adipose tissue. Particularly effective at targeting stubborn abdominal and visceral fat.

4.0/10 natty
Full breakdown →

4 / 10 natty scale / 4

Same lane

Both sit in the same class, but they are pointed at different goals: GHRP-2 at recovery, performance, longevity, Tesamorelin at cutting.

The tape

Core ratings

The same three rulers every entry on the site is scored with, read head to head.

GHRP-2Tesamorelin
4.0

Natty scale

1 natural · 10 heavy

4.0
3.5

Effectiveness

Documented effect · of 5Δ1

4.5
2.0

Side-effect severity

Documented burden · of 5Δ0.5

2.5

Cost side

Body-load fingerprint

Where each one actually lands its strain, on the calculator's thirteen channels. Tap a row for what it means and which labs track it.

GHRP-2Tesamorelin

Cardiometabolic

Hormonal

Injection & site care

Bars show strain at each one's typical protocol, not your dose. marks values inferred from side-effect data or category rather than hand-graded. For your numbers, run the calculator.

Logistics

The vitals

GHRP-2Tesamorelin
GH Secretagogue
Classmatch
GH Secretagogue
Subcutaneous
Routematch
Subcutaneous
100-300 mcg/day2-3x daily on empty stomach. Morning, post-workout, and bedtime.
Typical dose
1.3-2 mg/dayOnce daily subcutaneous injection
~33 minutes
Half-life
8-11 minutes
4-12 weeks
Typical run
12-26 weeks
Research chemical
Legal status
Prescription only
ProhibitedS2. Peptide Hormones, Growth Factors, Related Substances and Mimetics
WADAmatch
ProhibitedS2. Peptide Hormones, Growth Factors, Related Substances and Mimetics

Benefit side

What each is for

Shared goals carry both dots; a goal with one dot belongs to that side alone.

GHRP-2Tesamorelin
RecoveryPerformanceLongevityCutting

Run for

Growth Hormone ReleaseStimulates pulsatile GH release, mimicking natural physiology better than exogenous GH injection.
Recovery EnhancementElevated GH improves recovery from training and injuries.
Body CompositionGH elevation promotes fat loss and lean mass retention.
Anti-Aging/LongevityRestores youthful GH pulsatility which declines with age.

Documented upside

  • More potent GH release than GHRP-6 (lower ED50)
  • Minimal appetite stimulation compared to GHRP-6
  • Lower cortisol and prolactin elevation than GHRP-6
  • Signals via the GHS-R1a / PLC-PKC pathway, complementary and synergistic with GHRH analogs
  • Low desensitization risk at standard doses
+2 more on the full page

Run for

Visceral Fat ReductionSpecifically targets stubborn abdominal and visceral fat stores.
Body CompositionImproves overall body composition with focus on midsection.

Documented upside

  • Targeted visceral fat loss
  • FDA-approved with clinical data
  • Improved trunk fat distribution
  • Natural GH pattern preservation
  • Well-studied safety profile

The downsides

Side effects, aligned

Each entry's documented side effects, sorted onto the same body systems so the gaps and the overlaps are visible. Tap any effect for the detail.

GHRP-2Tesamorelin
Blood pressure & water

None documented

Blood sugar
Prolactin

None documented

Injection site
Other documented effects

The exit

Hormonal fallout & recovery

What each does to your own hormone axis while on, and what leaving it costs.

GHRP-2Tesamorelin
Not required
PCT
Not required
While-on only
What sticks
While-on only

GHRP-2

Does not affect HPT axis. No PCT required.

Tesamorelin

Does not suppress natural hormone production. No PCT required.

Read-out

How they separate

  1. 01

    Enhancement

    They land at almost the same point on the natty scale (4/10 vs 4/10): a similar distance beyond natural.

  2. 02

    Side-effect bill

    Tesamorelin's documented side-effect severity is heavier (2.5/5 vs 2/5). The body-load fingerprint above shows where that weight actually lands.

  3. 03

    Body load

    The widest gap at typical protocols is prolactin (GHRP-2 3.2/10 vs 0/10), then estrogen load (GHRP-2 1.7/10 vs 0/10).

  4. 04

    Coming off

    Neither requires PCT: both leave the natural testosterone axis running.

  5. 05

    Logistics

    typical runs are 4-12 weeks vs 12-26 weeks.

  6. 06

    Tested athletes

    Both are WADA-prohibited: neither belongs anywhere near tested competition.

Generated from each entry's data file. Descriptive, not a recommendation; nothing here is medical advice.