HGH vs MK-677: side-by-side comparison
Somatropin · Human Growth Hormone · Growth Hormone
Direct replacement of the body's growth hormone for recovery, fat loss, and anti-aging. Provides systemic benefits including improved body composition, sleep, skin quality, and healing.
Ibutamoren · MK677 · Nutrobal
An oral ghrelin mimetic that stimulates GH pulses. Technically not a peptide but a non-peptide agonist of the ghrelin receptor that increases growth hormone and IGF-1 levels.
7 / 10 natty scale / 4
Same lane
Both sit in the same class and are run for recovery. This is a like-for-like comparison: read the gaps as real trade-offs.
The tape
Core ratings
The same three rulers every entry on the site is scored with, read head to head.
Natty scale
1 natural · 10 heavyΔ3
Effectiveness
Documented effect · of 5Δ1
Side-effect severity
Documented burden · of 5
Cost side
Body-load fingerprint
Where each one actually lands its strain, on the calculator's thirteen channels. Tap a row for what it means and which labs track it.
Cardiometabolic
Organ strain
Hormonal
Systemic
Injection & site care
Bars show strain at each one's typical protocol, not your dose. ≈ marks values inferred from side-effect data or category rather than hand-graded. For your numbers, run the calculator.
Logistics
The vitals
Benefit side
What each is for
Shared goals carry both dots; a goal with one dot belongs to that side alone.
Run for
Documented upside
- Significant fat loss
- Enhanced recovery and healing
- Improved sleep quality
- Better skin elasticity and appearance
- Increased collagen synthesis
Run for
Documented upside
- Oral administration (no injections)
- Improved sleep quality
- Increased appetite
- Elevated IGF-1 levels
- Enhanced recovery
The downsides
Side effects, aligned
Each entry's documented side effects, sorted onto the same body systems so the gaps and the overlaps are visible. Tap any effect for the detail.
None documented
The exit
Hormonal fallout & recovery
What each does to your own hormone axis while on, and what leaving it costs.
HGH
Does not suppress natural hormone production in a way that requires PCT.
MK-677
Does not suppress testosterone. No PCT required.
Read-out
How they separate
- 01
Enhancement
HGH sits 3 points higher on the natty scale (7/10 vs 4/10): a bigger step beyond natural at its typical protocol.
- 02
Body load
The widest gap at typical protocols is cholesterol / apob (MK-677 2.8/10 vs 0/10), then heart structure (HGH 5.5/10 vs 2.8/10).
- 03
Coming off
Neither requires PCT: both leave the natural testosterone axis running.
- 04
Logistics
HGH runs as subcutaneous, MK-677 as oral; typical runs are 12-52 weeks vs 8-12 weeks.
- 05
Tested athletes
Both are WADA-prohibited: neither belongs anywhere near tested competition.
Generated from each entry's data file. Descriptive, not a recommendation; nothing here is medical advice.