DSIP vs TB-500: side-by-side comparison
Delta Sleep Inducing Peptide · Delta Sleep Peptide · Factor Delta
A 9-amino acid neuropeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, ~849 Da) first isolated from rabbit cerebral venous blood in 1974 and chemically characterized by Schoenenberger & Monnier in 1977. Promotes delta wave (slow-wave) sleep stages 3-4 NREM. Modulates GABA and serotonin systems. Animal studies report increased nocturnal GH pulses and altered stress-hormone responses, but the controlled human trials that tested this directly found no effect on GH/prolactin (Giusti et al. 1993) or on CRH-/meal-induced ACTH/cortisol (Späth-Schwalbe et al. 1995): so the often-repeated GH and cortisol claims are largely unproven in humans. Research peaked in the 1980s-90s but development stalled due to very short half-life and inconsistent clinical results. Evidence quality is low-moderate with mostly small, outdated studies.
Thymosin Beta-4 · TB4 · TB 500
Focuses on systemic healing, cell migration, and flexibility. A naturally occurring peptide present in almost all human cells that plays a key role in tissue repair and regeneration.
1 / 10 natty scale / 1
Same lane
Both sit in the same class and are run for health. This is a like-for-like comparison: read the gaps as real trade-offs.
The tape
Core ratings
The same three rulers every entry on the site is scored with, read head to head.
Natty scale
1 natural · 10 heavy
Effectiveness
Documented effect · of 5Δ2
Side-effect severity
Documented burden · of 5
Cost side
Body-load fingerprint
Where each one actually lands its strain, on the calculator's thirteen channels. Tap a row for what it means and which labs track it.
Cardiometabolic
Injection & site care
Bars show strain at each one's typical protocol, not your dose. ≈ marks values inferred from side-effect data or category rather than hand-graded. For your numbers, run the calculator.
Logistics
The vitals
Benefit side
What each is for
Shared goals carry both dots; a goal with one dot belongs to that side alone.
Run for
Documented upside
- May improve slow-wave sleep quality
- GH pulse increases seen in animal studies, but not confirmed in the one controlled human trial
- Stress-protective effects seen in animal models; a controlled human trial found no cortisol/ACTH effect
- Acts as an endogenous stress-limiting factor in animal research
- Generally well-tolerated with mild side effects (largest human trial, n=107, reported good tolerance aside from occasional headache)
Run for
Documented upside
- Systemic healing effects
- Reduced inflammation
- Improved flexibility
- Enhanced wound healing
- Promotes new blood vessel formation
The downsides
Side effects, aligned
Each entry's documented side effects, sorted onto the same body systems so the gaps and the overlaps are visible. Tap any effect for the detail.
None documented
None documented
The exit
Hormonal fallout & recovery
What each does to your own hormone axis while on, and what leaving it costs.
DSIP
Does not suppress the HPT axis. No PCT required. May indirectly support recovery through improved sleep quality (direct cortisol-normalizing effects have not been confirmed in controlled human trials).
TB-500
Does not affect hormones. No PCT required.
Read-out
How they separate
- 01
Enhancement
They land at almost the same point on the natty scale (1/10 vs 1/10): a similar distance beyond natural.
- 02
Coming off
Neither requires PCT: both leave the natural testosterone axis running.
- 03
Logistics
typical runs are 4-8 weeks vs 6-12 weeks.
Generated from each entry's data file. Descriptive, not a recommendation; nothing here is medical advice.